Mesenchymal
stem cells (MSCs) self-replicate and differentiate into a variety of cell types
such as osteoblasts, chondrocytes, adipocytes, and smooth muscle cells. These
capacities have made MSCs useful in studies of bone and cartilage regeneration.
One of the sources of human MSCs (hMSCs) is adult bone marrow, although they
occur at a rate of one per one-hundred-thousand nucleated cells, and the
available volume of bone marrow is limited. To secure the numbers of hMSCsrequired for tissue regeneration, the cell must be expanded ex vivo.
Although
hMSCs are stable ex vivo, it is possible that they undergo transformation to an
unlimited proliferation phenotype during expansion. Previous studies have
demonstrated that Ewing’s sarcoma is derived from MSCs. Ewing’s sarcoma is a
malignancy that primarily affects children and young adults, with a peak
incidence between the ages of 14 and 20 years. It arises mainly in bone and
less commonly in soft tissues. The t(11;22)(q24;q12) chromosomal translocation
generating EWS-FLI-1 fusion gene is found in 85% of cases. EWS-FLI-1 knockdown
inhibits cell proliferation in Ewing’s sarcoma cells. Read more>>>>>>>>>>>
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