PU.1 is a member of the Ezb transformation-specific
sequence family of transcription factors and is expressed mainly in
granulocytic, monocytic and B-lymphoid cells. The downregulation of PU.1 was
reported to play a role in the pathogenesis of various hematological
malignancies, including Acute Myeloid Leukemia (AML), multiple myeloma and Myelodysplastic
Syndrome (MDS).
PU.1 is also normally present in immature erythroid cells , and
several reports have indicated that their downregulation is required for
erythroid terminal differentiation. Constitutive upregulation of PU.1 is
believed to be the main cause for a blockade in the differentiation process of
Murine Erythroleukemia (MEL) cells. However, several findings indicate a requirement for PU.1 expression for
erythroid differentiation. Back et al.have reported an important study. They
produced a line of PU.1 deficient mice carrying a green fluorescent protein
reporter at this locus. They revealed that, PU.1 deficient fetal erythroid
progenitors lose their self-renewal capacity and undergo proliferation arrest,
premature differentiation and apoptosis. Read more>>>>>>>>>>>>
No comments:
Post a Comment